SUIGEN Vol.3  

Issued on November 27, 2018





§ Opening Interview


A Top Runner in Carbon Material Research

 ~ Leading to Practical Application of Fuel Cell Catalysts ~
    International Education and Research Center for Silicon Science, Graduate School of Science and Technology
    Professor Junichi Ozaki

    Japan boasts achievements in the development of new forms of carbon. Japanese companies are known for holding a two-thirds share of the global market for carbon fiber. Carbon materials come in various types and are used in diverse fields, including electronics, energy, and pharmaceuticals. Japan also leads the world by researching and developing carbon structures at the nanoscale level, such as carbon nanotubes, fullerenes, and graphene. Professor Junichi Ozaki is one of the top runners in carbon materials research.



Portable fuel cell stack using carbon alloy catalyst



§ Frontline


Tracing the Mysteries of Mitochondria

    Department of Cell Structure, Biological Information Division, Institute for Biological Regulation, Institute for Molecular and Cellular Regulation
    Professor Ken Sato

    You may have heard the name "mitochondria" at least once. They are tiny organelles found within the cells of our bodies, ranging from several tens to thousands in number. However, these organelles are more than just ordinary. They play a crucial role in all vital activities, such as movement, thinking, and digestion, by generating the energy necessary for these functions. Additionally, they have their own unique set of genes called mitochondrial DNA, which is known to be inherited exclusively from the mother (maternal inheritance). Professor Ken Sato and Associate Professor Miyuki Sato from the Institute for Biological Information Signal Research have been fascinated by the mysteries of mitochondria and have made significant contributions to their research.





Why Does the Combination of Radiation and Immunotherapy Enhance the Effectiveness of Cancer Treatment?

    ~ World's First Discovery Showing Involvement of DNA Repair ~
    Center for Graduate Education and Research Support, Graduate School of Medicine
    Research Lecturer Atsushi Shibata

    Atsushi Shibata, a research lecturer, focuses on DNA damage and its repair reactions during cancer treatment. In genetics, DNA serves as the blueprint for constructing our bodies. Traditional cancer treatments aim to damage the DNA of cancer cells; however, it is known that DNA can repair itself. Recent research has made significant progress in the study of DNA repair. In recent years, immunotherapy using "anti-PD-1 antibodies" has garnered attention in cancer treatment, and it has been reported that combining this with radiation therapy enhances treatment efficacy. The reason for this enhanced effect and its mechanism were previously unknown. However, the team led by Research Lecturer Shibata made a significant discovery from the perspective of DNA repair reactions following radiation exposure, which contributes to unravelling the underlying mechanism. His finding is the world's first research achievement demonstrating the involvement of DNA repair in cutting-edge immunotherapy.



Network Optimization Technology to Solve Society's Problems
    Faculty of Social and Information Studies
    Associate Professor Kiyohito Nagano

    Associate Professor Kiyohito Nagano specializes in mathematical optimization, particularly algorithmic research in discrete optimization targeting structures like networks. The concept of "submodularity," which abstracts networks, is also a central research theme. He is actively involved in research in artificial intelligence fields such as machine learning, a significant application area for discrete algorithms. He has published a book titled "Submodular Optimization and Machine Learning".





From the Fusion of Photochemistry and Medicine to the Study of Oxygen in Living Organisms
    Division of Molecular Science, Graduate School of Science and Technology
    Professor Seiji Tobita
    Professor Toshitada Yoshihara

    Cancer tissues are in low oxygen conditions due to abnormal cell proliferation. Cancer and many other diseases are deeply associated with oxygen deficiency (hypoxia). If we can image and visualize oxygen distribution in the body through luminescence, it can contribute to understanding the mechanisms underlying disease development. One of the research themes in Professor Seiji Tobita's laboratory is the design, synthesis, and evaluation of molecules (luminescent probes) that can detect specific biomolecules through luminescence. They have succeeded in imaging oxygen distribution in organ tissues, including cancer tissues, at a cellular level with high resolution and have made significant advances in this field.



§ Close-Up


A New Form of Research Support Pioneered by a Different Talent

    Center for Big Data Integration and Analysis, Initiative for Advanced Research Institute for Biological Regulation, Institute for Molecular and Cellular Regulation
    Professor Takayuki Asao

    Professor Takayuki Asao continues his research on glycans and cancer, applies for patents at the university, develops medical and training devices, and continues to secure funding grants. At the same time, he deepens collaboration with local medical institutions and readily provides advice and support to young researchers regarding their research plans. This talent has created a new support system for medical and life science research at Gunma University, one of the few in the country. Currently, he is taking on the challenge of building a physiological data integration system to accelerate the development of implantable medical devices within a large consortium composed of Shinshu University, Tohoku University, Gunma University, and other institutions.



§ Topics


Innovative Medical Technology Through Collaboration Between Medicine and Science

    Gunma University has been promoting the "Medical-Scientific-Engineering Integration for Innovative Healthcare Technology, Medical Devices, and Pharmaceuticals Project" since the 2014 academic year. This project involves close collaboration between researchers from the Faculty of Science and Technology and the Life and Medical Sciences field. Within this project, Assistant Professor Kazumi Tanaka from the Quality and Safety of Medical Care Course and Professor Takayuki Asao from the Future Advanced Research Institute's Big Data Integration Analysis Center have taken the lead in a research theme titled "Development of an Evaluation Device for Safe Central Venous Catheterization Techniques." The research and development of this device have been progressing smoothly, and it is being sold by the collaborative development company AlphaBio Co., Ltd. (Headquarters: Maebashi, Gunma Prefecture). It has received positive feedback through nationwide training seminars and other events.



Next-Generation Mobility: Research Accelerated with Completion of Base Facility


    The base facility for next-generation mobility research, constructed by Gunma University on the Aramaki Campus (Maebashi City), was completed in the spring of 2018, accelerating research activities. Establishing this base facility has strengthened collaboration with companies and enabled various experiments to be conducted.

    The role of the research center is to study and develop next-generation modes of transportation. Unlike similar research institutions, this center not only focuses on technological development but also conducts experiments using these technologies within society and engages in research and promotion of the cultural aspects of new transportation methods. Currently, the center's main pillars of activity are research on autonomous driving and slow mobility. One distinctive feature of the center's research on autonomous driving is its specialization in "Level 4" automation (fully autonomous vehicles without human drivers) for predetermined routes, such as shuttle buses running between JR Maebashi Station and Joshin Electric Railway Chuo Maebashi Station. The other pillar, slow mobility, refers to traffic using vehicles that travel at speeds slower than usual cars but faster than walking (less than 20 km/h). With support from the Japan Science and Technology Agency (JST), Gunma University has collaborated with the venture company Think Together Co., Ltd. (located in Kiryu City) to develop a low-speed electric bus called "eCOM-8" (nickname: MAYU). The company has already sold 19 units domestically and internationally.


Research and development facility building


§ GUNDAI Collection


Gunma University Faculty of Engineering Alumni Memorial Hall

    The Gunma University Faculty of Engineering Alumni Memorial Hall, located on the Kiryu Campus, was initially used as the main building of Kiryu Higher Dyeing School, the predecessor of the Gunma University Faculty of Science and Technology (established in 1915). It was completed in 1916.

    The school specialized in two fields: dyeing and textiles. Over the years, it went through various stages, including Kiryu Higher Industrial School and Kiryu Technical School, before becoming the Faculty of Engineering of Gunma University in 1949. In 2013, the Faculty of Engineering was reorganized into the Faculty of Science and Technology.

    The current building consists of a part of the original main building and an attached auditorium, which were relocated in the 1972 academic year. Despite enduring a century of wind and snow, the building has undergone several repairs, including a significant seismic retrofit in 2017.

    The wooden structure has a total floor area of 987 square meters. The main building primarily utilizes Japanese cedar as the building material, and elements of the Tudor architectural style can be seen in the decorative eaves and the shape of the entrance arch, influenced by British architecture. Upon entering the entrance, a double-height hall leads directly to the auditorium. This layout follows the "direct-administration school style" commonly found in school buildings of the late Meiji period. The former auditorium is single-story but spacious, with a two- to three-story high ceiling. The podium against a decorative wall and neatly arranged benches evoke a sense of an old-fashioned church.

    There are rooms dedicated to housing and exhibiting historical materials and a dye collection. The latter consists of approximately 4,361 actual dye samples collected from Europe and other regions between the establishment of Kiryu Higher Dyeing School and around 1945. Many of these dyes are no longer obtainable, making the collection nationally and globally invaluable. This building, the Faculty of Engineering Guardhouse, and the former main gate of Kiryu Higher Dyeing School were registered as a National Registered Tangible Cultural Property in 1998.

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